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Vaporizers are also popular for those who prefer not to inhale smoke.The devices concentrate the THC from the marijuana into a storage unit and the person then inhales the vapor, not the smoke.

In the United States, the Controlled Substances Act (CSA) of 1990 classifies marijuana as a Schedule I substance, which states it has no approved medical use and a high potential for abuse.According to the National Institute on Drug Abuse (NIDA), marijuana is the most abused drug in the US.Many states in the US have now legalized marijuana for medical or recreational use.Sativex is composed of standardized extracts of THC and cannabidiol and is available as an oral mucosal spray formulation.Studies from Lakhan, et al report that THC and cannabidiol (CBD) provide therapeutic benefit for Multiple Sclerosis (MS) spasticity (muscle stiffness/spasm) symptoms.GW Pharmaceuticals and Otsuka Pharmaceuticals announced results of three US Phase 3 trials in 2015 for the use of Sativex for the treatment of pain in patients with advanced cancer who experience inadequate analgesia during optimized chronic opioid therapy.

According to the study results, Sativex did not meet the primary endpoint of demonstrating a statistically significant difference from placebo for pain control.

Marijuana contains over 60 different cannabinoid compounds, and overall 400 different compounds have been identified in marijuana, including THC, cannabidiol (CBD), cannabinol, and β-caryophyllene, as noted by the National Institute of Drug Abuse (NIDA).

Marijuana may be smoked as a cigarette (called a joint or a nail) or in a pipe or bong.

The highest concentrations of THC are found in the dried flowers, or buds.

When marijuana smoke is inhaled, THC rapidly passes from the lungs into the bloodstream and is carried to the brain and other organs throughout the body.

Sativex, an oral sublingual spray, is approved for use in multiple sclerosis (MS) spasticity.